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Alzheimer's Mutation Could Lead to Unique Type of the Disease
— Nearly All APOE4 Homozygous Individuals Develop Alzheimer’s Emerging evidence from multiple research cohorts suggests that carrying two copies of the APOE4 gene variant is more than just a risk factor; it may drive a unique genetic form of Alzheimer’s disease. Data on clinical features, biomarkers, and pathology indicate that APOE4 homozygous individuals could have a distinct genetic trajectory in Alzheimer’s onset, according to Juan Fortea, MD, PhD, from the Hospital of Sant Pau in
Alzheimer's Mutation Could Lead to Unique Type of the Disease
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