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— Nearly All APOE4 Homozygous Individuals Develop Alzheimer’s Emerging evidence from multiple research cohorts suggests that carrying two copies of the APOE4 gene variant is more than just a risk factor; it may drive a unique genetic form of Alzheimer’s disease. Data on clinical features, biomarkers, and pathology indicate that APOE4 homozygous individuals could have a distinct genetic trajectory in Alzheimer’s onset, according to Juan Fortea, MD, PhD, from the Hospital of Sant Pau in

— Ongoing Quest for Reliable CIDP Biomarkers Accurate diagnosis of chronic inflammatory demyelinating polyneuropathy (CIDP) is often delayed or missed entirely, with standard options like intravenous immunoglobulin (IVIG), steroids, and plasma exchange offering inconsistent success, especially for certain CIDP subtypes. Although promising, validated biomarkers remain elusive, which could potentially revolutionize both diagnosis and therapy for this complex condition. "Biomarkers can be