Pathology

— Update from Lancet Commission incorporates vision loss, high LDL to risk factors PHILADELPHIA -- The Lancet Commission on dementia prevention, intervention, and care has expanded the list of modifiable risk factors linked to cognitive decline to 14, after new research conducted since its previous report in 2020. Vision loss and elevated low-density lipoprotein (LDL) cholesterol have been added to the commission's risk factor list, which previously included 12. This revised 57-page

— Replacing weekly servings of bacon or hot dogs with nuts and legumes linked to reduced dementia risk PHILADELPHIA – A long-term observational study involving 130,000 healthcare professionals found that eating processed red meat twice a week over several decades was associated with a higher likelihood of developing dementia. Participants from the Nurses' Health Study and the Health Professionals Follow-Up Study who consumed at least one-quarter of a daily serving of processed red meat —

— Nearly All APOE4 Homozygous Individuals Develop Alzheimer’s Emerging evidence from multiple research cohorts suggests that carrying two copies of the APOE4 gene variant is more than just a risk factor; it may drive a unique genetic form of Alzheimer’s disease. Data on clinical features, biomarkers, and pathology indicate that APOE4 homozygous individuals could have a distinct genetic trajectory in Alzheimer’s onset, according to Juan Fortea, MD, PhD, from the Hospital of Sant Pau in