cancer

— The impact of aspirin on colorectal cancer risk lessens with healthier living A prospective cohort study has revealed that the regular use of aspirin is linked to a lower incidence of colorectal cancer (CRC), but this benefit appears more pronounced in those leading less healthy lifestyles. For healthcare professionals with the most unfavorable lifestyle scores, the 10-year cumulative rate of CRC was found to be 2.12% for consistent aspirin users, compared to 3.40% for those who did not

— Replacing weekly servings of bacon or hot dogs with nuts and legumes linked to reduced dementia risk PHILADELPHIA – A long-term observational study involving 130,000 healthcare professionals found that eating processed red meat twice a week over several decades was associated with a higher likelihood of developing dementia. Participants from the Nurses' Health Study and the Health Professionals Follow-Up Study who consumed at least one-quarter of a daily serving of processed red meat —

— Age-Related Outcomes A retrospective analysis involving Medicare patients suggested that hormone therapy in older women with breast cancer was linked to a lower risk of developing dementia. The study showed that breast cancer patients who underwent hormone-modulating therapy had a 7% reduced likelihood of dementia over an average follow-up of 12 years compared with those who didn’t receive the therapy (HR 0.93, 95% CI 0.88-0.98, P=0.005), according to research led by Chao Cai, PhD, from the

— Elevated risk observed in women with deep infiltrating endometriosis or ovarian endometriomas A new population-based cohort study reveals that women with endometriosis, especially those with more severe forms, face a heightened risk of ovarian cancer. Compared to women without endometriosis, those with the condition have an increased risk of developing ovarian cancer (adjusted HR 4.20, 95% CI 3.59-4.91). This risk surge is particularly significant for type I ovarian cancers, such as

— Potential for durable responses with alternative antigen-targeted therapy A promising new treatment targeting a different antigen has shown success among patients with large B-cell lymphoma who previously relapsed after receiving CD19-directed CAR T-cell therapy (CAR19), according to findings from a phase I dose-finding study. In the study, 38 patients who had not responded to CAR19 achieved a 68% overall response rate and a 53% complete response rate following treatment with autologous

Recent studies indicate that engaging in moderate to vigorous physical activity may enhance the effectiveness of rituximab, a monoclonal antibody therapy used in treating chronic lymphocytic leukemia (CLL). Researchers based in England discovered that such exercise prompted a rise in natural killer cells, which, when combined with rituximab, help target and destroy cancerous cells in the bloodstream. Although experts acknowledge the growing evidence suggesting the immune-boosting capacity of

Researchers from Johns Hopkins Medicine have engineered an artificial lymph node that may offer a promising new way to fight cancer, according to findings demonstrated in both mice and human cells. This synthetic node, designed to function as a teaching hub for the immune system's T-cells, can potentially instruct them to recognize and target cancer cells more effectively, according to the study findings published recently online and in the June 6 edition of *Advanced Materials*. The

— Coverage on Cancer-Related News, Features, and Discussion Although nationwide suicide rates are steadily increasing, the trend among cancer patients is on the decline, according to a report. (Translational Psychiatry) An updated guideline from the American Society for Radiation Oncology emphasizes patient-centric care in radiation therapy for patients with bone metastases. New clinical guidelines now advocate for a personalized strategy when choosing contraceptive methods for women at risk of

The association between obesity and cancer is well-documented, sparking additional interest in understanding whether cancer risk is also influenced by diet. While smoking’s connection to lung cancer has been thoroughly established for many years, other lifestyle elements, such as diet, have not garnered the same level of attention. One significant observational study focusing on older Americans found that individuals on a low-fat diet had a reduced risk of lung cancer, while those consuming