Physical sciences

— Age-Related Outcomes A retrospective analysis involving Medicare patients suggested that hormone therapy in older women with breast cancer was linked to a lower risk of developing dementia. The study showed that breast cancer patients who underwent hormone-modulating therapy had a 7% reduced likelihood of dementia over an average follow-up of 12 years compared with those who didn’t receive the therapy (HR 0.93, 95% CI 0.88-0.98, P=0.005), according to research led by Chao Cai, PhD, from the

— Elevated risk observed in women with deep infiltrating endometriosis or ovarian endometriomas A new population-based cohort study reveals that women with endometriosis, especially those with more severe forms, face a heightened risk of ovarian cancer. Compared to women without endometriosis, those with the condition have an increased risk of developing ovarian cancer (adjusted HR 4.20, 95% CI 3.59-4.91). This risk surge is particularly significant for type I ovarian cancers, such as

— Potential for durable responses with alternative antigen-targeted therapy A promising new treatment targeting a different antigen has shown success among patients with large B-cell lymphoma who previously relapsed after receiving CD19-directed CAR T-cell therapy (CAR19), according to findings from a phase I dose-finding study. In the study, 38 patients who had not responded to CAR19 achieved a 68% overall response rate and a 53% complete response rate following treatment with autologous