WHO announces revisions to several recommendations in its upcoming guidelines on the treatment of opioid dependence and the community-based management of opioid overdose. Opioid dependence continues to be a significant driver of illness and death worldwide. In 2023, an estimated 316 million people globally used drugs, including about 61 million who reported non-medical use of opioids. Opioids remain responsible for the greatest share of drug-related harm, particularly fatal overdoses. Of the