Cancer

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Aspirin May Offer the Greatest CRC Risk Reduction for Those in Poor Health
— The impact of aspirin on colorectal cancer risk lessens with healthier living A prospective cohort study has revealed that the regular use of aspirin is linked to a lower incidence of colorectal cancer (CRC), but this benefit appears more pronounced in those leading less healthy lifestyles. For healthcare professionals with the most unfavorable lifestyle scores, the 10-year cumulative rate of CRC was found to be 2.12% for consistent aspirin users, compared to 3.40% for those who did not
Aspirin May Offer the Greatest CRC Risk Reduction for Those in Poor Health
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Executed by Firing Squad; Cancer Rates in Millennials; Heart Attacks Amid COVID
— Health Updates Curated by MedPage Today Staff Note: Some of the provided links may require a subscription or registration. The highest court in South Carolina has ruled to allow death sentences to be carried out via firing squad and the electric chair, alongside lethal injection. (AP via ABC News) A former organ transplant coordinator has been found guilty of unlawfully accessing medical records of Supreme Court Justice Ruth Bader Ginsburg in 2019. Prosecutors say the confidential information
Executed by Firing Squad; Cancer Rates in Millennials; Heart Attacks Amid COVID
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Jon Stewart Urges VA to Assist Veterans Affected by Post-9/11 Uranium Exposure
— Numerous veterans report severe health issues, many tied to radiation exposure Renowned comedian and activist Jon Stewart is urging the Biden administration to address an oversight in the expansive PACT Act, a veterans assistance bill, which neglected to cover American soldiers who were among the first responders post-9/11, and later fell ill after being stationed at a base heavily contaminated with radiation. In the months following the September 11 attacks, U.S. special operations forces
Jon Stewart Urges VA to Assist Veterans Affected by Post-9/11 Uranium Exposure
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Nasal Sprays for Treating Respiratory Infections; Paxlovid's Role in COVID Prevention
— Also on TTHealthWatch: Pediatric Diabetes Post-COVID TTHealthWatch is a weekly podcast from Texas Tech, hosted by Elizabeth Tracey, the director of electronic media at Johns Hopkins, and Dr. Rick Lange, president of Texas Tech University Health Sciences Center, El Paso. Each week, they delve into the most significant medical news. This episode's discussions include topics such as the efficacy of nasal sprays for respiratory infections, the preventive use of Paxlovid, endometriosis and
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Hormone Therapy May Lower Dementia Risk in Certain Older Breast Cancer Patients
— Age-Related Outcomes A retrospective analysis involving Medicare patients suggested that hormone therapy in older women with breast cancer was linked to a lower risk of developing dementia. The study showed that breast cancer patients who underwent hormone-modulating therapy had a 7% reduced likelihood of dementia over an average follow-up of 12 years compared with those who didn’t receive the therapy (HR 0.93, 95% CI 0.88-0.98, P=0.005), according to research led by Chao Cai, PhD, from the
Hormone Therapy May Lower Dementia Risk in Certain Older Breast Cancer Patients
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Women With Endometriosis Face Increased Risk of Ovarian Cancer
— Elevated risk observed in women with deep infiltrating endometriosis or ovarian endometriomas A new population-based cohort study reveals that women with endometriosis, especially those with more severe forms, face a heightened risk of ovarian cancer. Compared to women without endometriosis, those with the condition have an increased risk of developing ovarian cancer (adjusted HR 4.20, 95% CI 3.59-4.91). This risk surge is particularly significant for type I ovarian cancers, such as
Women With Endometriosis Face Increased Risk of Ovarian Cancer
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If CD19 CAR T-Cell Therapy Doesn't Work in Lymphoma, Consider a CD22 Option
— Potential for durable responses with alternative antigen-targeted therapy A promising new treatment targeting a different antigen has shown success among patients with large B-cell lymphoma who previously relapsed after receiving CD19-directed CAR T-cell therapy (CAR19), according to findings from a phase I dose-finding study. In the study, 38 patients who had not responded to CAR19 achieved a 68% overall response rate and a 53% complete response rate following treatment with autologous
If CD19 CAR T-Cell Therapy Doesn't Work in Lymphoma, Consider a CD22 Option
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Triple Negative Breast Tumor
Triple-negative breast cancer presents unique treatment challenges, but in many cases it can be managed effectively. Dr. Bonnie Sun, a breast cancer surgeon, provides insight into the nature of triple-negative breast cancer, the outlook for patients, and reasons to remain hopeful. What does “triple-negative” mean in breast cancer? Under normal circumstances, breast cells have receptors that respond to hormones like estrogen and progesterone, helping them grow and shrink depending on hormone
Triple Negative Breast Tumor
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Allergy or infection? Researchers uncover the key differences between these immune system reactions
Scientific team headed by Luís Graça, leading a Portuguese research group at iMM, uncovers how antibody production is controlled in different contexts, opening doors for new allergy treatments without compromising immune defense Antibodies play a crucial role in defending our bodies against infections, and their production is meticulously controlled by a specialized type of immune cells called follicular helper lymphocytes. A research group led by Luís Graça, group leader at Instituto de
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ECOG-ACRIN wraps up pioneering trial focused on Black patients with early-stage breast cancer
This impactful clinical trial aimed to go beyond outlining disparities in outcomes; it took a proactive step toward addressing these gaps to foster equity in breast cancer care. Its findings show that research, when specifically tailored to underrepresented populations, yields positive results. In a study carried out by the ECOG-ACRIN Cancer Research Group (ECOG-ACRIN), Black patients with early-stage breast cancer who received docetaxel chemotherapy every three weeks experienced fewer
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Fresh avenues uncovered for managing lung cancer in non-smokers
Advancing Precision Medicine by Integrating Genomic, Transcriptomic, Proteomic, and Clinical Data While smoking remains the leading cause of lung cancer, a rising number of cases in non-smokers—particularly among women—has been documented. Roughly 80% of lung cancer patients who never smoked receive treatments targeting specific protein mutations, like those in the EGFR and ALK genes. For those without such mutations, however, treatment often involves chemotherapy, which typically produces
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Promising outcomes seen with neoadjuvant immunotherapy in early-stage melanoma treatment
For patients with metastatic melanoma, administering immunotherapy before surgery has shown to be remarkably effective. In fact, in 59% of patients, this approach is so successful that additional post-surgery treatment isn't necessary. These results come from the newly published NADINA study. Led by experts from the Netherlands Cancer Institute, the NADINA trial has been recognized as one of the top eleven clinical studies projected to greatly impact healthcare in 2024, as stipulated by
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Decline in Suicide Rates Among Cancer Patients; Circadian Rhythm Enhancement; HIV Vaccine as Cancer Therapy?
— Coverage on Cancer-Related News, Features, and Discussion Although nationwide suicide rates are steadily increasing, the trend among cancer patients is on the decline, according to a report. (Translational Psychiatry) An updated guideline from the American Society for Radiation Oncology emphasizes patient-centric care in radiation therapy for patients with bone metastases. New clinical guidelines now advocate for a personalized strategy when choosing contraceptive methods for women at risk of
Decline in Suicide Rates Among Cancer Patients; Circadian Rhythm Enhancement; HIV Vaccine as Cancer Therapy?
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BSC initiates clinical validation of radiation-free breast cancer diagnostic method at Vall d'Hebron Hospital
QUSTom Project: Advancing Breast Cancer Diagnosis with 3D Ultrasound and Supercomputing, Led by Josep de la Puente from Barcelona Supercomputing Center The QUSTom project, backed by the European Union and managed under the guidance of the Barcelona Supercomputing Center (BSC-CNS), is breaking new ground by exploring a novel approach to medical imaging. Utilizing 3D tomographic ultrasound and advanced supercomputing, the project aims to enhance early breast cancer detection. In collaboration
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Low-fat diets could reduce lung cancer risk, especially in smokers
The association between obesity and cancer is well-documented, sparking additional interest in understanding whether cancer risk is also influenced by diet. While smoking’s connection to lung cancer has been thoroughly established for many years, other lifestyle elements, such as diet, have not garnered the same level of attention. One significant observational study focusing on older Americans found that individuals on a low-fat diet had a reduced risk of lung cancer, while those consuming
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UAB scientists reveal SRSF1 protein's rare capacity to interact with and unravel RNA G-quadruplexes
BIRMINGHAM, Ala. – RNA transcription is a vital genomic process, wherein a cell replicates the DNA sequence of a gene into an RNA copy. In research recently published in Nucleic Acids Research, University of Alabama at Birmingham's Professor Jun Zhang, Ph.D., alongside his team, explores the novel role of the protein SRSF1 in binding and unwinding intricate RNA Guanine-quadruplex structures (GQ). GQs are highly structured elements found in both DNA and RNA sequences. These G-quadruplexes
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In Medicine, ‘Women Aren’t Just Smaller Versions of Men’
Welcome to everyone. I’m Dr. John White, Chief Medical Officer here at WebMD. Let me ask you—does your biological sex influence your health? Could it factor into diagnoses, treatments, and the symptoms you experience? Absolutely. That’s something we now recognize, though it wasn’t so widely accepted 5, 10, or certainly 20 years ago. Fortunately, pioneers like today’s guest, Phyllis Greenberger, played a huge role in bringing attention to women's health research. Phyllis has a new book that
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John
John 30 May 2024 16:49
This is a groundbreaking discovery by Dr. Jun Zhang and his team at the University of Alabama at Birmingham. Understanding SRSF1's ability to bind and unfold RNA G-quadruplexes opens new avenues for treating diseases related to RNA splicing malfunctions, like cancer. The finding that SRSF1 prefers purine-rich sequences and can effectively unfold GQ structures is particularly significant. This research marks a crucial step towards better understanding the regulation of protein expression within cells and potentially developing new treatment strategies for various illnesses.
UAB scientists reveal SRSF1 protein's rare capacity to interact with and unravel RNA G-quadruplexes