Dimethyl sulfoxide (DMSO) and methylsulfonylmethane (MSM) are two closely related chemical compounds that have been explored for their potential to help with osteoarthritis. DMSO is generally applied to the skin, whereas MSM is available as a dietary supplement, often included with other elements such as glucosamine.

Bottom Line

Very limited studies have been done on the effectiveness of DMSO and MSM for easing symptoms of osteoarthritis. As a result, it's not clear whether these substances provide any benefit.

Safety

• The overall safety of DMSO and MSM is still not well established due to a lack of extensive research. Known side effects of DMSO include stomach discomfort, skin reactions, and a strong garlic-like taste or odor on the breath and body. Common side effects reported for MSM include allergic responses, digestive issues, and skin irritation.

• If you're considering using DMSO or MSM for managing osteoarthritis, it's important to talk to your doctor or healthcare provider.

For More Information

NCCIH Clearinghouse

The NCCIH Clearinghouse provides resources on complementary and integrative health methods, offering access to publications and scientific literature. It does not offer medical advice or referrals.

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Know the Science

Developed by NCCIH and NIH, Know the Science offers educational tools to clarify scientific concepts and empower individuals to make informed health decisions. These resources include interactive activities, videos, quizzes, and helpful guides that explain research findings in simpler terms.

Topics covered include explanations of research processes, how to interpret scientific journals, and understanding clinical trials.

PubMed®

PubMed®, managed by the National Library of Medicine, is a searchable database that provides access to article summaries and full citation details from health and science journals. It is a reliable source for academic publications on a variety of medical topics, including complementary health practices.

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

NIAMS supports research dedicated to uncovering the causes, treatment options, and prevention strategies for conditions affecting the joints, muscles, and skin. It also trains scientists in this field and shares up-to-date research findings with the public.

Toll-free number (U.S.): 1-877-22-NIAMS

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