The World Health Organization (WHO) is forming a Guideline Development Group (GDG) to produce data-driven recommendations regarding multiplex testing. This initiative aims to establish key frameworks for integrated diagnostic services, focusing on updated research concerning HIV, viral hepatitis, and other sexually transmitted infections (STIs).

Reliable and prompt diagnostic services play an essential role in halting, identifying, and treating HIV, hepatitis, and STIs—especially in countries with limited resources. As healthcare systems move toward more holistic, patient-centered delivery, multiplex testing is emerging as a valuable tool. This method allows the detection of several infections using a single biological sample and testing platform, improving efficiency, increasing reach, and reducing costs.

This forthcoming guideline will be the first to comprehensively review current knowledge and practical experiences with multiplex testing. While it will mainly address its use in HIV, hepatitis, and STIs, the document will also propose key integration strategies that support broader public health goals and open pathways for future multi-disease testing methods.

The GDG will meet virtually, including a scheduled session from 4–5 November 2025. These meetings aim to draft practical recommendations for both healthcare providers and individuals using self-tests. The group will also focus on developing guiding principles and addressing how to make the most effective use of limited resources while maximizing public health benefits.

Guideline Development Group Membership

Following WHO’s established methods for forming advisory bodies, the GDG consists of experts from various WHO regions who participate in an individual capacity. They were chosen by WHO staff based on their relevant expertise, experience as end-users such as clinicians or program leaders, and ability to represent communities affected by these infections. Members volunteer their time and are not paid for their involvement.

Request for Public Input

To support a transparent and inclusive process, WHO encourages individuals and organizations to review the background details of the GDG participants and share their thoughts. Feedback can be submitted by email to [email protected] by 29 September 2025. This input will help WHO create well-informed, inclusive guidelines that better reflect the needs of communities around the world.